Nateglinide is a medicinal drug used as the main active ingredient in medications to control blood glucose levels. It is a phenylalanine derivative of the meglitinide class of agents that shows hypoglycemic activity. It works by binding with a higher affinity to the SUR1 subunit. This active component metabolized by the cytochrome isoenzyme. The original drug and metabolites are mainly excreted in the urine and its half-life. It stimulates insulin secretion from the pancreas and is used in the treatment of type 2 diabetes.
Class of Drugs – Sulfonylureas
Molecular Formula – C19H27NO3
Molecular Weight - 317.4 g/mol
Working: It is approved for the treatment of type 2 diabetics. People with type 2 diabetes are unable to control blood glucose levels. This is caused by decreased secretion of insulin from the pancreas after meals and resistance of the cells to the effect of insulin. It stimulates the cells to remove glucose from the blood. This results in high levels of blood glucose. Nateglinide component works by stimulating the cells in the pancreas to form insulin in a manner.
Uses: This medicine is used with other drugs to control high blood sugar along with a proper diet and exercise program. It is recommended in people with type 2 diabetes. Controlling high blood sugar prevents kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Controlled diabetes may also decrease the risk of a heart attack or stroke. Nateglinide stimulates the body to produce more insulin. Insulin is a natural substance that allows the body to properly use sugar from the diet.
Popular Brands and Dosages: This medication is used in popular branded medicines as mentioned below:
- Starlix: 60 mg and 120 mg
Blood sugar should be checked and monitored regularly while taking this medicine.