Olmesartan-Amlodipine-Hydrochlorothiazide is a combination of three different active ingredients used to treat high blood pressure. It is a synthetic imidazole derivative and angiotensin II receptor antagonist with antihypertensive activity. Olmesartan binds to the angiotensin type 1 receptor subtype in vascular smooth muscle and adrenal gland to compete with angiotensin II for binding to the AT1 receptor. It prevents angiotensin II-induced vasoconstriction and interferes with angiotensin II-mediated aldosterone secretion to decrease aldosterone production and prevent aldosterone-stimulated sodium retention and potassium excretion.
Amlodipine is a calcium channel blocker with antihypertensive and antianginal properties. It inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, to prevent the vascular and myocardial contraction. Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. Its metabolite appears to preferentially bind to and accumulate in red blood cells.
Class of Drugs – Angiotensin receptor blocker, Calcium channel blocker, and diuretics
Molecular Formula – C56H63Cl2N11O15S2
Molecular Weight - 1265.2 g/mol
Working: This combination of ingredients has an angiotensin receptor blocker and amlodipine is a calcium channel blocker. Olmesartan-Amlodipine-Hydrochlorothiazide works by relaxing blood vessels so blood can flow more easily. And Hydrochlorothiazide is called a water pill and causes the body to get rid of extra salt and water by producing more urine.
Uses: This mentioned medication is indicated to treat high blood pressure by lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It contains three medications Olmesartan-Amlodipine-Hydrochlorothiazide. It is used to relax blood vessels so blood can flow more easily.
Popular Brands and Dosages: These 3-ingredients together used as the main active components in a popular brand medicine as given below:
- Tribenzor: 20 mg and 40 mg
It is necessary to continue taking this drug even if you feel well. It is important to complete the course of medicines as prescribed by the doctor.