Telmisartan / Hydrochlorothiazide is a combination of two active components, which is used in the treatment of high blood pressure. Telmisartan a non-peptide angiotensin II receptor antagonist that binds to the AT1 subtype receptor in vascular smooth muscle and adrenal gland. It leads to the inhibition of the angiotensin II-mediated aldosterone production. It decreases in sodium and water as well as an increase in potassium excretion results in a subsequent reduction in blood pressure.
Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. This component appears to bind to and accumulate in red blood cells. It is excreted by the kidneys. This is indicated for the treatment of hypertension and congestive heart failure. It acts as a xenobiotic, an environmental contaminant, a diuretic and an antihypertensive agent.
Class of Drugs – A non-peptide angiotensin II receptor antagonist + Diuretic
Molecular Formula – C33H30N4O2 + C7H8ClN3O4S2
Molecular Weight - 297.7 g/mol + 514.6 g/mol
Working: This effective medication works by relaxing blood vessels so blood can flow more smoothly. The water pill increases the amount of urine produced, especially while initiating the dose of this medication. Telmisartan / Hydrochlorothiazide also helps to relax the blood vessels so to smoothen the blood flow through arteries.
Uses: Given active component thiazide diuretic that is indicated to prevent the body from absorbing excessive salt that can cause fluid retention. Another component is an angiotensin II receptor antagonist that helps keep blood vessels from narrowing, which lowers blood pressure and improves blood flow. This combination Telmisartan / Hydrochlorothiazide is used to treat high blood pressure by lowering blood pressure. It may lower the risk of a stroke or heart attack.
Popular Brands and Dosages: This combination is used in a popular brand drug as given below:
- Micardis HCT: 40 mg + 12.5 mg and 80 mg + 12.5 mg
Do not use this medication together with any other medication that contains aliskiren in case of having diabetes.