Lovastatin is a medication, which is a lactone metabolite isolated from the fungus Aspergillus terreus. It shows cholesterol-lowering and potential antineoplastic activities. It is hydrolyzed to the active beta-hydroxy acid form that inhibits 3-hydroxyl-3-methylgutarylcoenzyme A reductase. It is an enzyme involved in cholesterol biosynthesis. Additionally, this component may induce tumor cell apoptosis and inhibit tumor cell invasiveness by inhibiting protein farnesylation and protein geranylgeranylation. This effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation.
Class of Drugs – HMG-CoA reductase inhibitors
Molecular Formula – C24H36O5
Molecular Weight - 404.5 g/mol
Working: This mentioned medication belongs to a class of drugs known as HMG-CoA reductase inhibitors. These drugs also are known as statins. This medication Lovastatin acts by slowing the production of cholesterol in the body.
Uses: This mentioned medication is approved along with a proper diet to help lower bad cholesterol and fats like LDL, triglycerides and raise good cholesterol in the blood. This statin drug works by decreasing the amount of cholesterol produced by the liver. Reducing bad cholesterol and triglycerides and maximizing good cholesterol reduces the risk of heart disease and helps prevent strokes and heart attacks.
Additionally, eating a proper diet includes a low-cholesterol/low-fat diet, other lifestyle changes that may help Lovastatin work better such as exercising, losing weight if overweight, and stopping smoking.
Popular Brands and Dosages: This active medication is used in a popular brand medicine as given below:
- Mevacor: 20 mg
A low-fat diet should be consumed while treating with this medicine. Do not consume alcohol or tobacco products, it may cause serious side effects.