Hydroxyurea (Hydroxycarbamide) is an active agent, which is a mono hydroxyl-substituted urea antimetabolite. It works by inhibiting the ribonucleoside diphosphate reductase that is an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates. So as to prevent the cells from leaving the G1/S phase of the cell cycle. It also exhibits radiosensitizing activity by balancing cells in the radiation-sensitive G1 phase and obstructing with DNA repair. It is an antimetabolite, which is available in the form of a capsule.
Class of Drugs – Antimetabolites
Molecular Formula – CH4N2O2
Molecular Weight - 76.055 g/mol
Working: This given drug Hydroxyurea works as a substitute for some parts that the cancer cells need to grow in the people with cancer. Cancer cells take in this medication that stops the cancer cell from growing. The growth of the cancer cells is faster than that of normal cells, so they are more affected by the drug. In people with the condition of sickle cell disease, this medicine changes the shape of red blood cells that makes it less likely for sickle cell crises to occur.
Uses: It is an antimetabolite drug indicated in people with sickle cell anemia to decrease the number of painful crises caused by the disease. It reduces the need for blood transfusions. It can be used in the treatment of certain types of cancer, for instance, chronic myelogenous leukemia, squamous cell carcinomas.
Popular Brands and Dosages: This mentioned drug is effective to treat cancer and sickle cell anemia. It is used as the active ingredient in a popular brand like given below:
- Hydrea: 500 mg
Alcoholic beverages and drugs like marijuana should be avoided while treating with this medication. Consult the doctor before stopping this medicine.