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What is CoAprovel?

CoAprovel is a medicine that contains two active substances, irbesartan and hydrochlorothiazide.

What is CoAprovel used for?

CoAprovel is for adults that have essential hypertension (high blood pressure) not adequately controlled by irbesartan or hydrochlorothiazide alone. ‘Essential’ it means that the hypertension might have no obvious cause.

How is CoAprovel used?

Doses higher than 300 mg irbesartan and 25 mg hydrochlorothiazide once a day are not recommended. CoAprovel may be added to some other treatments for hypertension.

How does CoAprovel work?

The combination of the two active substances has an additive effect, which reduces the blood pressure. By lowering the blood pressure, the risks is associated with high blood pressure, having a stroke, are reduced.

What benefit has CoAprovel shown during the studies?

CoAprovel was more effective than placebo (a dummy treatment) and then hydrochlorothiazide alone in lowering diastolic blood pressure. Enhancing the dose to 300 mg irbesartan and 25 mg hydrochlorothiazide might give a further decrease in blood pressure.