What is Stalevo?
Stalevo is an oral drug formulation developed by Novartis that contains a combination of three different drugs — carbidopa, levodopa and entacapone.
What is Stalevo used for?
Stalevo is used to treat Parkinson’s disease. The three work together to boost the amount of dopamine in the brain, thereby relieving the symptoms of Parkinson’s.
How does Stalevo work?
Levodopa in Stalevo is a precursor of dopamine, which can cross the blood-brain barrier and be converted into dopamine in the brain. When levodopa is administered orally, it is rapidly broken down by a biological process called decarboxylation that limits the amount reaching the brain. This is prevented by carbidopa, a dopa decarboxylase inhibitor, which inhibits the decarboxylation of levodopa, making more levodopa available for the brain.
What are contraindications of Stalevo?
Stalevo is contraindicated for patients who have demonstrated hypersensitivity to any component (carbidopa, levodopa, or entacapone) of the drug or its excipients. Other nonselective monoamine oxidase (MAO) inhibitors should not be used together with Stalevo.
What are other drug interactions with Stalevo?
Some drugs may interact with Stalevo such as anti-hypertensive agents or antidepressants. Follow the doctor’s advice regarding drug interactions.