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What is Comtess?

Comtess is a medicine that contains the active substance entacapone. It is available as brown-orange tablets (200 mg).

What is Comtess used for?

Comtess is used to treat patients with Parkinson’s disease. Comtess is used when several fluctuations cannot be treated with the standard levodopa-containing combination alone.

How is Comtess used?

Comtess is only used in combination either with levodopa and benserazide or with levodopa and carbidopa. It is taken as one tablet with each dose of the other medicine, up to a maximum of 10 tablets a day.

How does Comtess work?

The active substance in Comtess, entacapone, works to restore the levels of dopamine in the parts of the brain that control movement and coordination.

What is the risk associated with Comtess?

The most common side effects with Comtess (between 1 and 10 patients in 100) are dyskinesia (uncontrollable movements), nausea (feeling sick) and harmless urine discoloration.

How has Comtess been studied?

Comtess has been studied in a total of 376 patients with Parkinson’s disease, in two six-month studies measuring the effects of adding Comtess or placebo to the patient’s combination of levodopa and carbidopa or levodopa and benserazide.