Memantine Hydrochloride medication is a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate receptor antagonist. This active component binds to and inhibits cation channels of glutamanergic NMDA receptors found in the central nervous system. It prevents the prolonged influx of calcium ions and the related neuronal excitotoxicity so as to enhance the cognitive function. It is also a 5-hydroxytryptamine type 3 receptor and nicotinic receptor antagonist.
Class of Drugs – NMDA receptor antagonists
Molecular Formula – C12H22ClN
Molecular Weight - 215.76 g/mol
Working: The cause of Alzheimer’s disease is not known. People with this condition may be overexposed to the chemical glutamate. This cause is postulated by the scientists that can damage to the brain cells in people with Alzheimer’s disease. Given medicine Memantine Hydrochloride acts by restricting the receptors in the brain that glutamate would normally bind to. This reduces the harmful effect of glutamate in the brain and may help improve the symptoms of dementia.
Uses: This medication is indicated for the treatment of moderate to severe confusion or dementia associated with the Alzheimer's disease. It is not indicated to cure Alzheimer's disease, but it may help improve memory, awareness, and the ability to perform daily activities. Memantine Hydrochloride blocks the action of a certain natural substance in the brain like glutamate that is believed to be linked to symptoms of Alzheimer's disease.
Popular Brands and Dosages: Active component mentioned above is used in the following popular brand medicine:
- Namenda: 5 mg and 10 mg
The medical history of kidney problems, severe urinary tract infections, recent dietary change should be discussed with the doctor before consuming this medicine.