Metformin Hydrochloride medication shows antihyperglycemic and potential antineoplastic activities. This is the active component acts by inhibiting the complex I ubiquinone oxidoreductase of the mitochondrial respiratory chain. This process leads to increased cellular AMP to ATP ratio and activation of AMP-activated protein kinase. It further prevents hepatic gluconeogenesis, enhances insulin sensitivity and fatty acid oxidation that ultimately results in the decrease in glucose levels. This agent may exert antineoplastic effects through AMPK-independent inhibition of the mammalian target of rapamycin. It also inhibits tumor cell migration and invasion by restricting matrix metalloproteinase-9 expression.
Class of Drugs – An antihyperglycemic and potential antineoplastic drug
Molecular Formula – C4H12ClN5
Molecular Weight - 165.62 g/mol
Working: This given active component Metformin Hydrochloride works by decreasing the amount of glucose or sugar produced by the liver. It decreases the amount of glucose the body absorbs and increases the effect of insulin on the body. Insulin is a hormone that helps the body remove extra sugar from the blood. It results in a lowering of the blood sugar levels in the blood.
Uses: Medications composed with active ingredient Metformin Hydrochloride is approved for the treatment of high blood sugar. It should be followed with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in people with type 2 diabetes. Maintaining high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Controlling diabetes may also lessen the risk of a heart attack or stroke. It also helps to restore the proper response to the insulin naturally produced in the body. It also reduces the amount of sugar that the liver produces and that the stomach/intestines absorb.
Popular Brands and Dosages: The popular brand medicines contain this effective component is mentioned below:
- Glucophage: 500 mg, 850 mg, and 1000 mg
- Glucophage XR: 500 mg and 1000 mg
It is advisable to drink plenty of fluids while consuming this medicine unless otherwise directed by the doctor.